Skip to Main Content

Hemoglobinuria test

Definition

Hemoglobinuria test is a urine test that checks for hemoglobin in the urine.

Alternative Names

Urine - hemoglobin

How the Test is Performed

A clean-catch (midstream) urine sample is needed. The clean-catch method is used to prevent germs from the penis or vagina from getting into a urine sample. To collect your urine, you may get a special clean-catch kit from your health care provider that contains a cleansing solution and sterile wipes. Follow instructions exactly so that the results are accurate.

How to Prepare for the Test

No special preparation is necessary for this test. If the collection is being taken from an infant, a couple of extra collection bags may be necessary.

How the Test will Feel

The test involves only normal urination. There is no discomfort.

Why the Test is Performed

Hemoglobin is a molecule attached to red blood cells. Hemoglobin helps move oxygen and carbon dioxide through the body.

Red blood cells have an average life span of 120 days. After this time, they are broken down into parts that can make a new red blood cell. This breakdown takes place in the spleen, bone marrow, and liver. If the red blood cells break down in the blood vessels, their parts move freely in the bloodstream.

If the level of hemoglobin in the blood rises too high, then hemoglobin begins to appear in the urine. This is called hemoglobinuria.

This test may be used to help diagnose causes of hemoglobinuria.

Normal Results

Normally, hemoglobin does not appear in the urine.

What Abnormal Results Mean

Hemoglobinuria may be a result of any of the following:

  • A kidney disorder called acute glomerulonephritis
  • Burns
  • Crushing injury
  • Hemolytic uremic syndrome (HUS), a disorder that occurs when an infection in the digestive system produces toxic substances
  • Kidney infection
  • Kidney tumor
  • Malaria
  • Paroxysmal nocturnal hemoglobinuria, disease in which red blood cells break down earlier than normal
  • Paroxysmal cold hemoglobinuria, disease in which the body's immune system produces antibodies that destroy red blood cells
  • Sickle cell anemia
  • Thalassemia, disease in which the body makes an abnormal form or inadequate amount of hemoglobin
  • Thrombotic thrombocytopenic purpura (TTP)
  • Transfusion reaction
  • Tuberculosis

References

Landry DW, Bazari H. Approach to the patient with renal disease. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 106.

Riley RS, McPherson RA. Basic examination of urine. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 23rd ed. St Louis, MO: Elsevier; 2017:chap 28.

Review Date: 07/04/2019

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright ©2019 A.D.A.M., Inc., as modified by University of California San Francisco. Any duplication or distribution of the information contained herein is strictly prohibited.

Information developed by A.D.A.M., Inc. regarding tests and test results may not directly correspond with information provided by UCSF Health. Please discuss with your doctor any questions or concerns you may have.

Share