17-Ketosteroids urine test

Definition

17-ketosteroids are substances that form when the body breaks down male steroid sex hormones called androgens and other hormones released by the adrenal glands in males and females, and by the testes in males.

How the Test is Performed

A 24-hour urine sample is needed. You will need to collect your urine over 24 hours. Your health care provider will tell you how to do this. Follow instructions exactly to ensure accurate results.

How to Prepare for the Test

Your provider will ask you to temporarily stop any medicines that may affect the test results. Be sure to tell your provider about all the medicines you take. These include:

• Antibiotics
• Aspirin (if you are on long-term aspirin)
• Birth control pills
• Diuretics (water pills)
• Estrogen

DO NOT stop taking any medicine before talking to your provider.

How the Test will Feel

The test involves normal urination. There is no discomfort.

Why the Test is Performed

Your provider may order this test if you have signs of a disorder associated with abnormal levels of androgens.

Normal Results

Normal values are as follows:

• Male: 7 to 20 mg per 24 hours
• Female: 5 to 15 mg per 24 hours

Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your doctor about the meaning of your specific test results.

What Abnormal Results Mean

Increased levels of 17-ketosteroids may be due to:

• Adrenal gland problems such as tumor, Cushing syndrome
• Imbalance of sex hormones in females (polycystic ovary syndrome)
• Ovarian cancer
• Testicular cancer
• Overactive thyroid
• Obesity
• Stress

Decreased levels of 17-ketosteroids may be due to:

• Adrenal glands not making enough of their hormones (Addison disease)
• Kidney damage
• Pituitary gland not making enough of its hormones (hypopituitarism)
• Removal of the testicles (castration)

Risks

There are no risks with this test.

References

Bertholf RL, Cooper M, Winter WE. Adrenal cortex. In: Rifai N, ed. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 6th ed. St Louis, MO: Elsevier; 2018:chap 66.

Chernecky CC, Berger BJ. Metyrapone (cortisol) - 24-hour urine. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. St Louis, MO: Elsevier Saunders; 2013:787.